As a result of the implementation of the activity the facts were determined that the problem of circulatory diseases (hereinafter referred to as CVD) and the development of primary and secondary prevention measures should be solved in a personalized manner for each country and region. In this connection the analysis of the prevalence of circulatory system diseases and their risk factors in different population groups of the highly urbanized region - Kuzbass was carried out. Modern solutions in the field of HCC risk management, methods of their prevention, treatment and necessary rehabilitation of HCC applied in different population groups, clinical and organizational technologies of prevention, treatment and rehabilitation of HCC in the presence of comorbid and/or occupational pathology in certain high-risk cohorts of the population were determined.